Dr. Sukant Das

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    KIDNEY CARE CONSULTATIONS

    CONSULTATIONS FOR SERVICES FOR VARIOUS KIDNEY RELATED DISEASES

    Permacath Insertion.

    Permacath Insertion.
    Dialysis is the lifeline of Chronic Kidney diseases [CKD] / Renal failure patients. AV Fistual is the most common dialysis access method. If it fails or can’t be done then Permcath placement is 2nd preferred method of long term Hemodialysis. A flexible tube which is inserted into vein having 2 hollow bores is called as Permcath. Generally Permcath is inserted in internal jugular vein and very rarely in femoral vein in the groin region. One hollow bore carries blood from body to dialysis machine whereas the other bore carries blood from dialysis machine to body. There’s a cuff which holds catheter in place protecting from infections which also acts like a barrier.

    BEFORE THE PROCEDURE

    1. Patient is kept in NBM for 5-6 hours before the procedure. 2. If the patient is already on blood thinners or any particular medicines or allergic to any medicines, infections in past then the doctor should be reported about the same. 3. Patient should undergo physical examination test, blood tests and colour Doppler test before the procedure.

    DURING THE PROCEDURE

    A flexible tube called as IV Cannula is inserted into back side of the hand inorder to deliver drugs directly into the vein. Patient is asked to lie flat on the bed thereby sedatives are administered intravenously to relax the body and relieve any pain till the procedure is completed. Antiseptic solution or sterile is rubbed at body region wherein catheter is to be inserted. Doctor records oxygen level in the blood. After sedating the patient doctor will guide a wire into the superior venacava or right atrium of heart through internal jugular vein. In this way doctor creates the tunnel and thereby guides the catheter into the right atrium of the heart. Cuff keeps the catheter in place or holds it in place which is present under the chest wall. The region where catheter leaves chest wall is stitched and transparent dressing is applied over the stitched area. Cathlab Imaging tests are conducted after the permcath insertion inorder to confirm the Permcath position. This procedure lasts for approximately 45-50 mins. The advantages of Permcath are like it is less prone to infection and moreover it lasts for much longer duration than jugular catheter.

    Haemodialysis

    Haemodialysis

    Hemodialysis is a treatment to filter wastes and water from your blood, as your kidneys did when they were healthy. Hemodialysis helps control blood pressure and balance important minerals, such as potassium, sodium, and calcium, in your blood.

    Hemodialysis can help you feel better and live longer, but it’s not a cure for kidney failure.

    What happens during hemodialysis?

    During hemodialysis, your blood goes through a filter, called a dialyzer, outside your body. A dialyzer is sometimes called an “artificial kidney.”

    At the start of a hemodialysis treatment, a dialysis nurse or technician places two needles into your arm. You may prefer to put in your own needles after you’re trained by your health care team. A numbing cream or spray can be used if placing the needles bothers you. Each needle is attached to a soft tube connected to the dialysis machine.

    Diagram of hemodialysis blood flow from your arm into the tube, past a pressure monitor, a blood pump, and a heparin pump, which prevents clotting. Blood flows past another pressure monitor before entering the dialyzer, or filter. Filtered blood continues past a venous pressure monitor, an air trap and air detector, and an air detector clamp, and returns to your arm.
    During hemodialysis, your blood is pumped through a filter, called a dialyzer.

    The dialysis machine pumps blood through the filter and returns the blood to your body. During the process, the dialysis machine checks your blood pressure and controls how quickly

    • blood flows through the filter
    • fluid is removed from your body

    What happens to my blood while it’s in the filter?

    Blood enters at one end of the filter and is forced into many, very thin, hollow fibers. As your blood passes through the hollow fibers, dialysis solution passes in the opposite direction on the outside of the fibers. Waste products from your blood move into the dialysis solution. Filtered blood remains in the hollow fibers and returns to your body.

    Diagram of blood flow from the top of the dialyzer to the bottom. Dialysis solution flows in the opposite direction, from bottom to top. Cross-section shows hollow fibers inside the dialyzer, where wastes pass from the blood into the solution.
    In the filter, your blood flows inside hollow fibers that filter out wastes and extra salt and water.

    Your nephrologist—a doctor who specializes in kidney problems—will prescribe a dialysis solution to meet your needs. The dialysis solution contains water and chemicals that are added to safely remove wastes, extra salt, and fluid from your blood. Your doctor can adjust the balance of chemicals in the solution if

    • your blood tests show your blood has too much or too little of certain minerals, such as potassium or calcium
    • you have problems such as low blood pressure or muscle cramps during dialysis

    Can the dialyzer do everything my kidneys once did?

    No. Hemodialysis can replace part, but not all, of your kidney function. Dialysis will help improve your energy level, and changes you make to your diet can help you feel better. Limiting how much water and other liquid you drink and take in through foods can help keep too much fluid from building up in your body between treatments. Medicines also help you maintain your health while on dialysis.

    Where can I have hemodialysis?

    You can receive treatment at a dialysis center or at home. Each location has its pros and cons

    Dialysis center

    Most people go to a dialysis center for treatment. At the dialysis center, health care professionals set up and help you connect to the dialysis machine. A team of health care workers will be available to help you. You will continue to see your doctor. Other team members may include nurses, health care technicians, a dietitian, and a social worker.

    Set schedule
    You’ll have a fixed time slot for your treatments, usually three times per week: Monday, Wednesday, and Friday; or Tuesday, Thursday, and Saturday. Each dialysis session lasts about 4 hours. When choosing a dialysis schedule, think about your work and child care or other caregiving duties.

    Nighttime option
    Some dialysis centers offer nighttime treatments. These treatments occur at the dialysis center 3 nights a week while you sleep, which takes longer. Getting longer overnight dialysis treatments means

    • your days are free.
    • you have fewer diet changes.
    • your liquid allowance (how much liquid you can drink) is closer to normal.
    • you may have a better quality of life than with a standard hemodialysis schedule. Longer treatment sessions may reduce your symptoms.

    How do I find a dialysis center?
    Your doctor, nurse, or social worker can help you find a dialysis center that’s convenient for you. Under Medicare rules, you have the right to choose the dialysis center where you’ll receive treatment. Your doctor will give your medical information to the dialysis center you choose.

    Most large cities have more than one dialysis center to choose from. You can visit the centers to see which one best fits your needs. For example, you can ask about a center’s rules for laptop and cellphone use, as well as for having visitors. You may want the center to be close to your home to save travel time. If you live in a rural area, the closest dialysis center may be far from your home. If you’d have a hard time getting to the dialysis center, you may want to consider home dialysis treatments such as home hemodialysis or peritoneal dialysis.

    treatments over the internet.

    Peritoneal dialysis.

    Peritoneal dialysis.

    What is peritoneal dialysis and how does it work?

    Peritoneal dialysis is a treatment for kidney failure that uses the lining of your abdomen, or belly, to filter your blood inside your body. Health care providers call this lining the peritoneum.

    A few weeks before you start peritoneal dialysis, a surgeon places a soft tube, called a catheter, in your belly.

    When you start treatment, dialysis solution—water with salt and other additives—flows from a bag through the catheter into your belly. When the bag is empty, you disconnect it and place a cap on your catheter so you can move around and do your normal activities. While the dialysis solution is inside your belly, it absorbs wastes and extra fluid from your body.

    Diagram of peritoneal dialysis shows a bag of dialysis solution connected to a catheter going into the abdominal cavity—also outlines the peritoneum.
    Peritoneal dialysis

    After a few hours, the solution and the wastes are drained out of your belly into the empty bag. You can throw away the used solution in a toilet or tub. Then, you start over with a fresh bag of dialysis solution. When the solution is fresh, it absorbs wastes quickly. As time passes, filtering slows. For this reason, you need to repeat the process of emptying the used solution and refilling your belly with fresh solution four to six times every day. This process is called an exchange.

    You can do your exchanges during the day, or at night using a machine that pumps the fluid in and out. For the best results, it is important that you perform all of your exchanges as prescribed. Dialysis can help you feel better and live longer, but it is not a cure for kidney failure.

    How will I feel when the dialysis solution is inside my belly?

    You may feel the same as usual, or you may feel full or bloated. Your belly may enlarge a little. Some people need a larger size of clothing. You shouldn’t feel any pain. Most people look and feel normal despite a belly full of solution.

    What are the types of peritoneal dialysis?

    You can choose the type of peritoneal dialysis that best fits your life:

    • continuous ambulatory peritoneal dialysis (CAPD)
    • automated peritoneal dialysis

    The main differences between the two types of peritoneal dialysis are

    • the schedule of exchanges
    • one uses a machine and the other is done by hand

    If one type of peritoneal dialysis doesn’t suit you, talk with your doctor about trying the other type.

    CAPD doesn’t use a machine. You do the exchanges during the day by hand.

    You can do exchanges by hand in any clean, well-lit place. Each exchange takes about 30 to 40 minutes. During an exchange, you can read, talk, watch television, or sleep. With CAPD, you keep the solution in your belly for 4 to 6 hours or more. The time that the dialysis solution is in your belly is called the dwell time. Usually, you change the solution at least four times a day and sleep with solution in your belly at night. You do not have to wake up at night to do an exchange.

    Drawing of a person reading during CAPD. A bag of fresh dialysis solution hangs from a pole and is connected to a tube that has a clamp. The tube connects to a transfer set, a disposable tube that connects to another tube that enters the person’s abdomen. Tubing also connects from the transfer set to the drain bag on the floor.
    During an exchange, you can read, talk, watch television, or sleep.

    Automated peritoneal dialysis. A machine does the exchanges while you sleep.

    With automated peritoneal dialysis, a machine called a cycler fills and empties your belly three to five times during the night. In the morning, you begin the day with fresh solution in your belly. You may leave this solution in your belly all day or do one exchange in the middle of the afternoon without the machine. People sometimes call this treatment continuous cycler-assisted peritoneal dialysis or CCPD.

    Where can I do peritoneal dialysis?

    You can do both CAPD and automated peritoneal dialysis in any clean, private place, including at home, at work, or when travelling.

    Before you travel, you can have the manufacturer ship the supplies to where you’re going so they’ll be there when you get there. If you use automated peritoneal dialysis, you’ll have to carry your machine with you or plan to do exchanges by hand while you’re away from home.

    How do I prepare for peritoneal dialysis?

    Surgery to put in your catheter

    Before your first treatment, you will have surgery to place a catheter into your belly. Planning your catheter placement at least 3 weeks before your first exchange can improve treatment success.

    Although you can use the catheter for dialysis as soon as it’s in place, the catheter tends to work better when you have 10 to 20 days to heal before starting a full schedule of exchanges.

    Your surgeon will make a small cut, often below and a little to the side of your belly button, and then guide the catheter through the slit into your peritoneal cavity. You’ll receive general or local anesthesia, and you may need to stay overnight in the hospital. However, most people can go home after the procedure.

    Kidney transplantation

    Kidney transplantation

      A kidney transplant is a surgical procedure to place a healthy kidney from a living or deceased donor into a person whose kidneys no longer function properly. The kidneys are two bean-shaped organs located on each side of the spine just below the rib cage. Each is about the size of a fist. Their main function is to filter and remove waste, minerals and fluid from the blood by producing urine.
    When your kidneys lose this filtering ability, harmful levels of fluid and waste accumulate in your body, which can raise your blood pressure and result in kidney failure (end-stage kidney disease). End-stage renal disease occurs when the kidneys have lost about 90% of their ability to function normally. Common causes of end-stage kidney disease include:
    • Diabetes
    • Chronic, uncontrolled high blood pressure
    • Chronic glomerulonephritis — an inflammation and eventual scarring of the tiny filters within your kidneys (glomeruli)
    • Polycystic kidney disease
    People with end-stage renal disease need to have waste removed from their bloodstream via a machine (dialysis) or a kidney transplant to stay alive. At Mayo Clinic, health care professionals trained in many medical specialties work together as a team to ensure favorable outcomes from your kidney transplant. Having all of this subspecialized expertise in a single place, focused on you, means that you're not just getting one opinion — your care is discussed among the team, your test results are available quickly, appointments are scheduled in coordination, and your transplant care team works together to determine what's best for you.

    Insertion of percutaneous CAPD catheter

    Insertion of percutaneous CAPD catheter,

    Background

    A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal catheter placement and obesity. The aim of this study was to determine whether patients with large BMI can also choose the percutaneous technique for peritoneal dialysis catheter insertion.

    Conclusions

    Despite the challenges that may be encountered with patients who have a large BMI, the percutaneous technique seems to be a safe and effective approach to placing a peritoneal dialysis catheter.

    Diabetes and High BP related Kidney diseases

    Diabetes and High BP related Kidney diseases

    What is diabetic kidney disease?

    Diabetic kidney disease is a type of kidney disease caused by diabetes.

    Diabetes is the leading cause of kidney disease. About 1 out of 3 adults with diabetes has kidney disease.1

    The main job of the kidneys is to filter wastes and extra water out of your blood to make urine. Your kidneys also help control blood pressure and make hormones that your body needs to stay healthy.

    Illustration of an upper body showing the location of the kidneys.
    Your kidneys are located in the middle of your back, just below your rib cage.

    When your kidneys are damaged, they can’t filter blood like they should, which can cause wastes to build up in your body. Kidney damage can also cause other health problems.

    Kidney damage caused by diabetes usually occurs slowly, over many years. You can take steps to protect your kidneys and to prevent or delay kidney damage.

    What are other names for diabetic kidney disease?

    Diabetic kidney disease is also called DKD, chronic kidney disease, CKD, kidney disease of diabetes, or diabetic nephropathy.

    How does diabetes cause kidney disease?

    High blood glucose, also called blood sugar, can damage the blood vessels in your kidneys. When the blood vessels are damaged, they don’t work as well. Many people with diabetes also develop high blood pressure, which can also damage your kidneys. Learn more about high blood pressure and kidney disease.

    What increases my chances of developing diabetic kidney disease?

    Having diabetes for a longer time increases the chances that you will have kidney damage. If you have diabetes, you are more likely to develop kidney disease if your

    • blood glucose is too high
    • blood pressure is too high

    African Americans, American Indians, and Hispanics/Latinos develop diabetes, kidney disease, and kidney failure at a higher rate than Caucasians.

    You are also more likely to develop kidney disease if you have diabetes and

    • smoke
    • don’t follow your diabetes eating plan
    • eat foods high in salt
    • are not active
    • are overweight
    • have heart disease
    • have a family history of kidney failure
    A woman having her blood pressure checked by a health care professional.
    If you have diabetes, you are more likely to develop kidney disease if you have high blood pressure.

    How can I tell if I have diabetic kidney disease?

    Most people with diabetic kidney disease do not have symptoms. The only way to know if you have diabetic kidney disease is to get your kidneys checked.

    Health care professionals use blood and urine tests to check for diabetic kidney disease. Your health care professional will check your urine for albumin and will also do a blood test to see how well your kidneys are filtering your blood.

    You should get tested every year for kidney disease if you

    • have type 2 diabetes
    • have had type 1 diabetes for more than 5 years
    One vial with a blood sample and another vial with a urine sample.
    Health care professionals use blood and urine tests to check for kidney disease.

    How can I keep my kidneys healthy if I have diabetes?

    The best way to slow or prevent diabetes-related kidney disease is to try to reach your blood glucose and blood pressure goals. Healthy lifestyle habits and taking your medicines as prescribed can help you achieve these goals and improve your health overall.

    Reach your blood glucose goals

    Your health care professional will test your A1C. The A1C is a blood test that shows your average blood glucose level over the past 3 months. This is different from the blood glucose checks that you may do yourself. The higher your A1C number, the higher your blood glucose levels have been during the past 3 months.

    The A1C goal for many people with diabetes is below 7 percent. Ask your health care team what your goal should be. Reaching your goal numbers will help you protect your kidneys.

    To reach your A1C goal, your health care professional may ask you to check your blood glucose levels. Work with your health care team to use the results to guide decisions about food, physical activity, and medicines. Ask your health care team how often you should check your blood glucose level.

    Man measuring the level of glucose in his blood.
    Protect your kidneys by keeping your blood glucose under control.

    Control your blood pressure

    Blood pressure is the force of your blood against the wall of your blood vessels. High blood pressure makes your heart work too hard. It can cause heart attack, stroke, and kidney disease.

    Your health care team will also work with you to help you set and reach your blood pressure goal. The blood pressure goal for most people with diabetes is below 140/90 mm Hg. Ask your health care team what your goal should be.

    Man having his blood pressure checked by a health care professional.
    Protect your kidneys by keeping your blood pressure under control.

    Medicines that lower blood pressure can also help slow kidney damage. Two types of blood pressure medicines, ACE inhibitors and ARBs, play a special role in protecting your kidneys. Each has been found to slow kidney damage in people with diabetes who have high blood pressure and DKD. The names of these medicines end in –pril or –sartan. ACE inhibitors and ARBs are not safe for women who are pregnant.

    Develop or maintain healthy lifestyle habits

    Healthy lifestyle habits can help you reach your blood glucose and blood pressure goals. Following the steps below will also help you keep your kidneys healthy

    • Stop smoking.
    • Work with a dietitian to develop a diabetes meal plan and limit salt and sodium.
    • Make physical activity part of your routine.
    • Stay at or get to a healthy weight.
    • Get enough sleep. Aim for 7 to 8 hours of sleep each night.

    Learn more about these tips to manage diabetes.

    Take medicines as prescribed

    Medicines may be an important part of your treatment plan. Your health care professional will prescribe medicine based on your specific needs. Medicine can help you meet your blood glucose and blood pressure goals. You may need to take more than one kind of medicine to control your blood pressure.

    Couple talking with a pharmacist.
    Talk to your health care professional or pharmacist about all of the medicines you take, including over-the-counter medicines.

    How can I cope with the stress of managing my diabetes?

    Managing diabetes isn’t always easy. Feeling stressed, sad, or angry is common when you are living with diabetes. You may know what to do to stay healthy but may have trouble sticking with your plan over time. Long-term stress can raise your blood glucose and blood pressure, but you can learn ways to lower your stress. Try deep breathing, gardening, taking a walk, doing yoga, meditating, doing a hobby, or listening to your favorite music. 

    Does diabetic kidney disease get worse over time?

    Kidney damage from diabetes can get worse over time. However, you can take steps to keep your kidneys healthy and help slow kidney damage to prevent or delay kidney failure. Kidney failure means that your kidneys have lost most of their ability to function—less than 15 percent of normal kidney function. However, most people with diabetes and kidney disease don’t end up with kidney failure.

    Kidney biopsy

    Kidney biopsy

    What is a Kidney Biopsy?

    A kidney biopsy involves taking one or more tiny pieces (samples) of your kidney to look at with special microscopes. The microscopes make it possible to see the samples in greater detail.

    The biopsy sample may be taken in one of two ways:

    1. Percutaneous (through the skin) biopsy: a needle placed through the skin that lies over the kidney and guided to the right place in the kidney, usually with the help of ultrasound.
    2. Open biopsy: the kidney sample is taken directly from the kidney during surgery.
      The kidney sample is then sent to a doctor (pathologist) who looks at it with microscopes. He or she will check for any signs of disease.

    What are the reasons for doing a kidney biopsy?


    Some kidney problems can often be found with blood and urine tests, a sonogram (an image made by ultrasound) or other special x-rays, and a physical exam rather than a biopsy. But in some patients with certain types of kidney disease, and those with a kidney transplant that is not working well, a correct diagnosis can only be made with a kidney biopsy.

    Specific reasons to do a kidney biopsy include:

    • Blood in the urine (hematuria) or protein in the urine (proteinuria)
    • Abnormal blood test results
    • Acute or chronic kidney disease with no clear cause
    • Nephrotic syndrome and glomerular disease (which happens when the filtering units of the kidney are damaged)

    A kidney biopsy may also help to find:

    • If a disease is getting better with treatment or if it is getting worse. It may also show a problem that cannot be cured, but can be slowed down by other therapy.
    • How much permanent damage has happened in the kidney.
    • Why a transplanted kidney is not working well and helps your doctor decide on further treatment.
    • A kidney tumor.
    • Other unusual or special conditions.
    • If a certain treatment is hurting your kidneys

    Your healthcare provider should explain the reasons for the kidney biopsy. You should know why it is necessary, the benefits, and any risks. You will be asked to sign a consent (permission) form to make sure you are aware of any risks. Be sure you understand the risks before you sign the consent form. You may want to write down a list of questions about the biopsy.

    What are the possible risks of kidney biopsy?


    The risks of kidney biopsy are very small, but they should be discussed with your healthcare provider. As in other medical and surgical procedures, certain complications may happen even though every effort is taken to prevent them. A blood transfusion may be needed if serious bleeding occurs. Rarely, surgery may be needed to fix a blood vessel that is damaged during the procedure.

    How should you prepare for the biopsy?


    For two weeks before the biopsy, you should not take aspirin, over-the-counter pain medicines such as aspirin, ibuprofen, naproxen, Advil®, Nuprin®, or other medicines that may cause thinning of the blood. These medicines can change the way the blood clots and raise the risk of bleeding. For the same reason, you should stop taking some supplements such as fish oil. Blood and urine samples are usually taken before the kidney biopsy to make sure you do not have an infection or other condition. Your doctor may also want you to change other medications before the biopsy. You may be told to not eat or drink for eight hours before the procedure.

    How is the biopsy done?


    A kidney biopsy is usually done in a hospital. An overnight stay may be needed to watch for any problems. You may be awake with only light sedation, or asleep under general anesthesia. You will be lying face down with a pillow under your rib cage. If the biopsy is done on a transplanted kidney, you will be lying on your back.

    Percutaneous biopsy:


    The kidney is found using a sonogram, x-ray images, or both. Sometimes, an injection of dye into your veins may be needed to help the doctor find the kidney and important blood vessels. Once the biopsy site is found, your skin is marked, and cleaned where the biopsy needle will be inserted. You will receive a local anesthetic to numb the area where the biopsy needle enters. You will be asked to take in a deep breath and hold it as the doctor puts in the needle. When the needle pushes through the skin to the kidney, you may feel a "pop" or pressure. It is important to stay still and to hold your breath (about 45 seconds or less). Sometimes two needle passes are needed to get enough of the kidney sample for diagnosis. When enough is taken, the needle is removed and a bandage is placed over the needle puncture site. The entire procedure, from start to finish, usually lasts about one hour. Sometimes the biopsy may take longer than an hour.

    Open kidney biopsy:


    Some patients should not have a percutaneous biopsy because they may have a history of bleeding problems. For these patients, an open operation may be done where the surgeon can actually see the kidney to get a good sample to study.

    After the test


    You may need to rest in bed for 12 to 24 hours after the biopsy, as directed by the doctor. Staying still on bed helps to heal the site where the kidney sample was taken and lessen the chance of bleeding. Your blood pressure and pulse are checked often to look for any signs of bleeding inside your body, or other problems. Blood tests are also done. You may eat and drink fluids after the biopsy. If your blood tests, blood pressure and pulse are stable, you should be allowed to leave the hospital the next day.

    Your doctor will talk to you about physical activity and things to watch for after going home from the hospital. Heavy lifting, strenuous exercise, including contact sports, and sexual intercourse should be avoided for two weeks after the biopsy. If you had an open biopsy, be sure to ask your doctor for any specific instructions you need to follow after the surgery.

    Test results


    After the kidney sample is taken, it is sent to specially trained pathologists who will read and interpret your kidney biopsy. It often takes three to five days to get the full biopsy results. In some cases, you may have a partial or full report within 24 hours or less.

    THINGS TO REMEMBER
    Before the biopsy:

     

    • Talk with your health care provider to make sure you understand the need for a biopsy and the risks and benefits.
    • Tell your doctor about any allergies you have and medicines you take.
    • Avoid blood thinning medications and supplements.
    • Avoid food and fluid for eight hours before the test.

    After the biopsy:

     

    • Follow your doctor's instructions.
    • Rest in bed for 12 to 24 hours.
    • Avoid blood thinning medications.
    • Report any problems, such as:
      • Bloody urine for more than 24 hours after the biopsy
      • Unable to pass urine
      • Fever
      • Worsening pain at the biopsy site
      • Feeling faint or dizzy

    Glomerular diseases

    Glomerular diseases

    Kidneys have tiny structures that do the work called nephrons. Each of your kidneys contains about one million nephrons. Each nephron has a small blood vessel that brings in unfiltered blood, a glomerulus (glow-mare-Yule-us) that filters the blood, a tubule that caries away filtered waste materials in the urine, and a small blood vessel that returns filtered blood to the body. Diseases that injure the glomeruli are known as glomerular diseases. Read more about the kidney and glomerulus here.

    Your Kidneys

    A healthy kidney

    Your blood carries oxygen and nutrients to your organs and tissues, and carries waste products to be flushed out of your body. Your kidneys control this process.

    Your Kidneys:

    • Control the balance of water in your body
    • Tell your body when to start and stop making oxygen-carrying red blood cells
    • Control how acidic your blood is
    • Filter your blood and pass the waste products on to your bladder as urine
    • Control your blood pressure

    Your kidneys do three main jobs:

    1. Carry blood to and from the filters inside the kidney
    2. Filter blood
    3. Carry waste to your bladder

    Symptoms of Kidney Disease

    Kidney diseases can cause abnormalities in each kidney function, for example:

    • Abnormal control of the amount of water in your body causes accumulation of too much water resulting in swelling (edema)
    • Telling your body to stop making red blood cells causes too few red blood cells in the blood (anemia)
    • Abnormal control of how acidic your blood is causes too much acid in the blood (acidosis)
    • Reduced filtering of blood causes accumulation of waste products (such as urea) in blood (uremia)
    • Abnormal control of your blood pressure causes higher than normal blood pressure (hypertension)

    Parts of the Nephron

    The Nephron

    Nephros is the Greek word for kidney. Your kidney doctor is called a nephrologist because he treats kidney diseases.

    The tiny structures that do the work in your kidneys are called nephrons. Each of your kidneys contains about one million nephrons.

    Each nephron has a small blood vessel that brings in unfiltered blood, a glomerulus (glow-mare-Yule-us) that filters the blood, a tubule that caries away filtered waste materials in the urine, and a small blood vessel that returns filtered blood to the body.

    The Glomerulus

    Capillary

    Glomerular Capillaries

    Glomerular Disease

    Diseases that injure glomeruli (plural for glomerulus) are called glomerular diseases. Laboratory analysis of the urine from people who have glomerular disease often shows protein in the urine (proteinuria) and blood in the urine (hematuria).

    Proteinuria and Hematuria

    Urinary tract infections

    Urinary tract infections

    What is a Urinary Tract Infection (UTI) in Adults?

    A UTI is when bacteria gets into your urine and travels up to your bladder. UTIs cause more than 8.1 million visits to health care providers each year. About 60% of women and 12% of men will have at least one UTI during their lifetime.

    How Does the Urinary Tract Work?

    The role of the urinary tract is to make and stores urine. Urine is one of the waste products of your body. Urine is made in the kidneys and travels down the ureters to the bladder. The bladder stores the urine until it is emptied by urinating through the urethra, a tube that connects the bladder to the skin. The opening of the urethra is at the end of the penis in a male and above the vaginal opening in a female. The kidneys are a pair of fist-sized organs in the back that filter liquid waste from the blood and remove it from the body in the form of urine. Kidneys balance the levels of many chemicals in the body (sodium, potassium, calcium, phosphorous and others) and check the blood's acidity. Certain hormones are also made in the kidneys. These hormones help control blood pressure, boost red blood cell production and help make strong bones. Normal urine has no bacteria in it, and the one-way flow helps prevent infections. Still, bacteria may get into the urine through the urethra and travel up into the bladder.

    Symptoms

    When you have a UTI, the lining of the bladder and urethra become red and irritated just as your throat does when you have a cold. The irritation can cause pain in your lower abdomen pelvic area and even lower back, and will usually make you feel like urinating more often. Burning or pain when urinating is the most common symptom. You may even feel a strong urge or need to urinate but only get a few drops. This is because the bladder is so irritated that it makes you feel like you have to urinate, even when you don't have much urine in your bladder. At times, you may lose control and leak urine. You may also find that your urine smells bad and is cloudy. Kidney infections often cause fevers and upper back pain - usually on one side or the other. Kidney infections may also often cause nausea and vomiting. These infections need to be treated at once because a kidney infection can spread into the bloodstream and cause a life-threatening health issue.

    Causes

    Large numbers of bacteria live in the area around the vagina and rectum, and also on your skin. Bacteria may get into the urine from the urethra and travel into the bladder. They may even travel up to the kidney. But no matter how far they go, bacteria in the urinary tract can cause problems. Just as some people are more prone to colds, some people are more prone to UTIs. Women are more likely to get a UTI than men because women have shorter urethras than men, so bacteria have a shorter distance to travel to reach the bladder. Some factors that can add to your chances of getting a UTI are:

    Body Factors

    Women who have gone through menopause have a change in the lining of the vagina and lose the protection that estrogen provides, that lowers the chance of getting a UTI. Some women are genetically predisposed to UTIs and have urinary tracts that make it easier for bacteria to cling to them. Sexual intercourse can also affect how often you get UTIs.

    Birth Control

    Women who use diaphragms have also been found to have a higher risk of UTIs when compared to those who use other forms of birth control. Using condoms with spermicidal foam is also known to be linked to greater risk of getting UTIs in women.

    Abnormal Anatomy

    You are more likely to get a UTI if your urinary tract has an abnormality or has recently had a device (such as a tube to drain fluid from the body) placed in it. If you are not able to urinate normally because of some type of blockage, you will also have a higher chance of a UTI. Anatomical abnormalities in the urinary tract may also lead to UTIs. These abnormalities are often found in children at an early age but can still be found in adults. There may be structural abnormalities, such as outpouchings called diverticula, that harbor bacteria in the bladder or urethra or even blockages, such as an enlarged bladder, that keep the body from draining all the urine from the bladder.

    Immune System

    Issues such as diabetes (high blood sugar) also put people at higher risk for UTIs because the body is not able to fight off germs as well.

    Diagnosis

    If you are worried about a UTI, then you should talk with your health care provider. UTIs can be found by analyzing a urine sample. The urine is examined under a microscope for bacteria or white blood cells, which are signs of infection. Your health care provider may also take a urine culture. This is a test that detects and identifies bacteria and yeast in the urine, which may be causing a UTI. If you ever see blood in your urine, you should call your health care provider right away. Blood in the urine may be caused by a UTI but it may also be from another problem in the urinary tract. If you are having fevers and symptoms of a UTI, or symptoms that won't go away despite therapy, then you should call a health care provider. You may need further tests, such as an ultrasound or CT scan, to check the urinary tract.

    Treatment

    There are two types of UTIs: simple and complicated. Simple UTIs are infections that happen in healthy people with normal urinary tracts. Complicated UTIs happen in abnormal urinary tracts or when the bacteria causing the infection cannot be treated by many antibiotics. Most women have simple UTIs, while the UTIs in men and children should be thought of as complicated.

    Simple UTI

    A simple UTI can be treated with a short course of antibiotic meds. A short, 3-day course of an appropriate antibiotic will often treat most uncomplicated UTIs. However, some infections may need to be treated longer. Pain and the urge to urinate often go away after a few doses, but you should still take the full course of the antibiotic to ensure all the UTI is treated, even if you feel better. Unless UTIs are fully treated, they can often return. You should also drink plenty of liquids, especially around the time of a UTI. Postmenopausal women with UTIs may be helped by topical (vaginal) hormone replacement with estrogen. Since some patients may have other medical issues that prevent them from using estrogen, you should talk with your health care provider before starting any treatment.

    Complicated UTI

    If the UTI is a complicated UTI, then a longer course of antibiotics is given. Sometimes the antibiotic therapy may be started intravenously (IV) in the hospital. After a short period of IV antibiotics, the antibiotics are given by mouth for up to 2 weeks. Kidney infections are often treated as a complicated UTI.

    After Treatment

    Symptoms of UTIs often improve within a few days of antibiotics. As long as all UTI symptoms are resolved after the course of antibiotics is complete, you do not need another urine culture to prove that the infection is gone. Depending on the situation, if you have a complicated UTI, you may need a urine culture to show that the UTI is completely gone. If your symptoms don't go away even after antibiotics, then you may need a longer course of antibiotic, a different antibiotic, or different way of taking it. Between 20% and 40% of women who have a UTI will have another. Men are less likely to get a UTI in the first place. But if they get one, they are likely to have another because the bacteria tend to hide inside the prostate. If you get UTIs often (3 or more per year), then you should see your health care provider. Your health care provider might want to do more tests (such as checking if the bladder empties) to find out why. If you keep getting UTIs, a longer course of low-dose antibiotics or taking an antibiotic after sex may help. There are also methods of self-testing that your health care provider may arrange that let you diagnosis and treat your UTIs at home